E.Diane Williamson
University of Strathclyde, UK
Title: Exploring Immunity, Inflammation & Infection
Biography:
Abstract:
This presentation will cover novel approaches to vaccination, which have been specifically designed to curtail disease outbreaks in resource poor settings. A dual route vaccination approach will be described, in which a priming dose will be administered by sub-cutaneous injection by a health professional, whilst a booster dose is incorporated in an enteric coated -capsule for oral self-administration. This approach to vaccination will be exemplified by data gained from an experimental model of Middle Eastern Respiratory Syndrome (MERS) and will include considerations of vaccine antigen production and characterisation, the development of vaccine formulations, characterisation of the immune responses induced and identification of the immune correlates of protection. This approach is adaptable to other pathogens which have potential for epidemic spread and to exemplify the generic nature of this approach, the data gained with a bacterial pathogen will also be mentioned.The preclinical development of this approach to vaccination will be described with an indication of the route to clinical development and expected clinical presentation.